![]() One ICSI cycle each was performed in 2 patients, with successful fertilization, but no pregnancy. Under treatment, two patients with normal sperm concentrations induced a spontaneous pregnancy. ![]() Major side-effects were not observed, but half of the patients complained of minor degrees of dizziness, weakness, nausea or sweating during medication. In all 11 patients, antegrade ejaculation could be induced (sperm counts: 3.9–276.0 × 10 6/mL). Ten patients with retroperitoneal lymph node dissection performed because of testicular cancer, and one with aortic surgery (thromboendarterectomy) were treated in an open, uncontrolled study with imipramine given at a daily oral dose increasing from 25 to 50 mg for 7 days prior to the planned ejaculation or the expected ovulation of the female partner. We evaluated the use of the tricyclic antidepressant imipramine in a new ovarian cycle-dependent dose regime for reversal of retrograde ejaculation in 11 patients desiring fertility. Without further therapy, achieving paternity may be impossible. Retrograde ejaculation is a known complication following retroperitoneal lymph node dissection.
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